Samarin

KNOW THE QUALITY OF YOUR SILYMARIN (MILK THISTLE)

About Product

Silymarin, a flavonoid complex extracted from the seeds of Milk Thistle, has been used medicinally for centuries, most commonly for the treatment of liver and gallbladder disorders.* Silymarin/Milk Thistle is the subject of more than 80 clinical studies registered with the US National Institutes of Health.

Silymarin, like all herbal extracts, in natural form is poorly absorbed by the body to offer clinical benefits. It must be modified or formulated. Making Silymarin bioavailable is particularly challenging.

SILYMARIN’S POOR SOLUBILITY

Silymarin consists of two primary and most active compounds known as silybin A & B. When taken orally, silybin takes many hours for the body to absorb in the gastrointestinal tract,

and meanwhile a lot of it is excreted out in bile and urine. In its natural form, Silymarin thus cannot clinically deliver health benefits. Silymarin is also known as Milk Thistle because of the milkly sap in the leaves of the plant,

which is indigenous to the Mediterranean region and now grown in many parts of the world.

IMPROVING BIOAVAILABILITY

Manufacturers have developed proprietary and patented formulations and techniques to convert silybin into highly absorbable forms. The methods include combining isolated silybin with other molecules; encasing it into the structure of another molecule and safely delivering it to target liver cells; converting it into soluble derivatives; breaking silybin into “nano” size particles; and formulating it into tablets that can float in the stomach and slowly release the active compounds over time.

The increased absorption has shown to augment bioavailability 3 to 30 times the normal silybin, depending on the reformulation and the delivery mechanism. The higher the bioavailability, the lower the dose required to obtain therapeutic value.

HOW TO TELL HOW GOOD IS YOUR SILYMARIN?

Not all of the techniques and reformulations have been successfully deployed. As a result, Silymarin products in the market vary widely in solubility and bioavailability.

STANDARD TESTS

Only lab analysis can cofrm the solubility and bioavailability of the product. The acceptable standards are well established in the U.S. Pharmacopeia (USP) and the British Pharmacopeia (BP).

TEST METHODS

And the test method itself is important: HPLC (high-performance liquid chromatography) is more accurate than the less sensitive UV (Ultraviolet) Spectroscopy, which can exaggerate the solubility measure.

The solubility and bioavailability facts are generally not mentioned on the product label. It is up to the consumer to inquire about these critical measures of Silymarin quality, including the test method used to analyze the product.

Samarin

Facts about the brand

Samarin contains high grade of Silymarin manufactured at a GMP facility.

Samarin has been tested by an independent lab showing its soluble silymarin content is on average 105.8% of the product's label claim, in compliance with US Pharmacopoeia (USP 38) specifcations.

Samarin has been tested by an independent lab demonstrating it dissolves twice the rate of some leading brands.

Samarin has been tested by an independent lab confrming that 98.5% to 101.5% of the label amount dissolves in 45 minutes, signifcantly higher than the 75% minimum established as the US Pharmacopoeia's most recent standard (USP 38).

All tests of product quality were perfomed with HPLC and in accordance with standardized test methods.

Samarin

Samarin contains high grade of Silymarin manufactured at a GMP facility.

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Benefits Of Silymarin (Milk Thistle)

In studies up to five years long, milk thistle slightly improved liver function and decreased the number of deaths in people with liver disease.

Research showed that milk thistle improved control of blood sugar in people with diabetes with and without liver disease.

Research suggests that silymarin improves blood and urine markers associated with diabetic kidney disease.

Several studies of milk thistle in liver disease caused by viruses or alcohol report improvements in liver tests.

Limited research showed that milk thistle reduced the severity of allergic nasal symptoms.

Milk thistle has been used traditionally to treat Amanita phalloides mushroom poisoning.

Early research suggests that milk thistle, alone or given with vitamin E, improves antioxidant status.

In women undergoing artificial fertilization (in vitro fertilization, IVF), silymarin used in combination with standard therapy has demonstrated mixed results.

An herbal preparation containing milk thistle may be effective in decreasing heartburn.

Non-human research suggests cholesterol-lowering effects of milk thistle.

Several studies suggest possible benefits of milk thistle to treat or prevent liver damage caused by drugs or toxic chemicals.

An herbal preparation containing milk thistle may be effective in decreasing menopausal symptoms.

In early research, a preparation of milk thistle and other supplements has demonstrated a beneficial effect on people with various neurodegenerative disorders, including multiple sclerosis (MS), Parkinson's disease, and Alzheimer's disease.

In human research, milk thistle reduced symptoms of obsessive compulsive disorder (OCD).

Early evidence suggests that milk thistle has anti-inflammatory effects in people with osteoarthritis.

Early research in breast cancer patients suggests that silymarin helps ease radiotherapy-induced toxic skin reactions compared to standard care.